Chemical synthesis of interferon gamma — ASN Events
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  2. Poster Session 1 and Drinks
  3. Chemical synthesis of interferon gamma

Chemical synthesis of interferon gamma (#129)

Yuankun Dao 1 , Lin Han 1 , Hanxuan Wang 1 , Suwei Dong 1
  1. Peking University, State Key Laboratory of Natural and Biomimetic Drugs, and Department of Chemical Biology, School of Pharmaceutical Sciences, Beijing, China

Interferon gamma (IFN-γ) is an important N-glycosylated protein produced primarily by T-lymphocytes and natural killer cells.[1]  As a cytokine that is crucial for innate and adaptive immunity against viral infection, IFN-γ also exhibits anti-proliferative, immunoregulatory and proinflammatory activities.[2]  Herein, we described our studies toward the synthesis of IFN-γ via an α-selective lysine ligation. The synthetic protein exhibits comparable anti-cancer activity to recombinant IFN-γ in an anti-proliferation assay.[3]

  1. [1] a) Wheelock, E. F. Science 1965, 149, 310; b) Stewart, W. E. II., Nature 1980, 286, 110.
  2. [2] a) Wallach, D.; Fellous, M.; Revel, M. Nature 1982, 299, 833; b) Schroder, K.; Hertzog, P. J.; Ravasi, T.; Hume, D. A. J. Leukoc. Biol. 2004, 75, 163.
  3. [3] Dao, Y.; Lin, H,; Wang, H.; Dong. Org. Lett. 2019, 21, 3265–3270