GAS infection are responsible for over 500,000¹ deaths each year, and this number is still increasing. Vaccination is considered as a useful approach to enhance the host immunity against infection, and it has helped to prevent and even eradicate many infectious diseases so far. Herein we developed a potent peptide-polymer based vaccine against GAS infection. Our fully synthetic peptide vaccine candidates against group A streptococcus (GAS) were composed of J8 GAS B-cell epitope alongside with a universal helper T-cell epitope PADRE. Alkyne based peptide (J8-PADRE) was conjugated with azide based polymer named Poly methyl acrylate (PMA) by Copper-Catalyzed Alkyne-Azide Cycloaddition (CuAAC). PMA-J8-PADRE formed nanoparticle size (146±8) and PDI (0.190±0.02) measured using dynamic light scattering (DLS). PMA is one of the most widely explored bio-medical polymers because of its biocompatibility². Lipids including 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC), Didodecyldimethylammonium bromide ( DDAB) was used for liposome formulation and PMA-J8-PADRE loaded into liposome. The liposomes were coated with a layer by layer approach based on charge-charge interaction between cationic trimethyl chitosan (TMC) and anionic Sodium alginate (Alg)³, vaccine candidates alone and CTB-adjuvants. Mice (C57/BL) were immunized with seven different compounds by oral gavage. PBS was used as negative control with a single oral immunization (100μg of the respective vaccines in 30μL PBS).  All groups of mice that received GAS vaccine developed anti-GAS antibodies as determined by ELISA. The addition of CTB did not result in greater anti-GAS antibody titres. In fact, mice immunized without CTB had greater anti-GAS antibody titres than mice immunized with CTB because CTB can lower the immune response to oral vaccination⁴. Liposomes and coating liposomes did not enhance vaccine efficacy, thus we demonstrated that single antigen-polymer conjugate. The enhanced vaccine efficacy, lowered dose, and simple and cost-effective process of producing the coated nanoliposomes should be particularly useful in developing potent peptide-based vaccines to prevent infection.