PNA-Encoded Molecules to Program Assemblies and Reactions   — ASN Events
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PNA-Encoded Molecules to Program Assemblies and Reactions   (#42)

Nicolas Winssinger 1
  1. University of Geneva, Geneva, Switzerland

The programmable nature of nucleic acid hybridization has inspired a number of applications beyond their natural function in heredity.  Peptide Nucleic Acids (PNA) are endowed with attractive properties for this endeavor as they are more robust and form more stable duplex than their natural counter parts. Several applications from our laboratory to encode and program self-assemblies of small molecules, template chemical reactions or display multimeric ligands or fold peptides to constrain their conformation will be presented.

 

References:

  1. PNA as a Biosupramolecular Tag for Programmable Assemblies and Reactions, S. Barluenga, N. Winssinger, Chem. Res. 2015, 48, 1319-1331
  2. DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules, Sci., 2015, 6, 739-744.
  3. Identification of Covalent Bromodomain Binders from DNA Display of Small Molecules, Chem. Int. Ed. 2015, 54, 6057-61.
  4. Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization, T. Machida, S. Dutt, N. Winssinger, Chem. Int. Ed. 2016, 55, 8595-8.
  5. Nucleic-acid templated chemical reaction in a live vertebrate, L. Holtzer, I. Oleinich, M. Anzola, K. K. Sadhu, M., E. Lindberg, Gonzalez-Gaitan, N. Winssinger, ACS Central Science,2016,2, 394-400.
  6. Critical Analysis of Rate Constants and Turnover Frequency in Nucleic Acid-Templated Reactions: Reaching Terminal Velocity, D. Chang, E. Lindberg, N. Winssinger, Am. Chem. Soc. 2017, 139, 1444-1447.
  7. Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells, T. Machida, A. Novoa, E. Gillon, S. Zheng, J. Claudinon, T. Eierhoff, A. Imberty, W. Römer, N. Winssinger Chem. Int. Ed. 2017,56, 6762-6766.
  8. Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection, J. Sayers, R.J. Payne, N. Winssinger, Sci.2018, 9, 896-903.
  9. Luciferase-induced photoreductive uncaging of small-molecule effectors, E. Lindberg, S. Angerani, M. Anzola, N. Winssinger, Nature Commun. 2018, 9, 3539