Gate2Brain, Opening the Gate to CNS — ASN Events
  1. Schedule
  2. Peptide Delivery/Peptide Membrane Interactions
  3. Gate2Brain, Opening the Gate to CNS

Gate2Brain, Opening the Gate to CNS (#64)

Meritxell Teixido 1
  1. IRB Barcelona, Barcelona, Spain

Gate2Brain technology consist on a toolbox of peptides able to cross the blood-brain barrier (BBB) and carry  compounds covalently attached (including small molecules, peptides, proteins, antibodies,  plasmids, siRNA or mRNA loaded nanoparticles, etc…) that cannot cross this barrier unaided. They have proofed to carry these cargoes in vitro and in vivo. These peptide shuttles use the existing transport mechanisms at the BBB without affecting the normal functioning and preserving brain homeostasis.

By improving the delivery of therapeutic candidate to the central nervous system (CNS), we will ensure immediate impact in many CNS diseases patients. In addition, in a broader perspective, Gate2Brain technology may help to repurpose existing therapies previously rejected because of difficulty to reach the brain, accelerating the translation towards clinical development. Gate2Brain will also result in the application of lower concentrations of therapeutic agent, thereby significantly lowering systemic side effects and reducing the cost of the treatment.

Gate2Brain peptides combine protease resistance, capacity to carry a wide range of cargoes thanks to their versatility, low production costs, and low immunogenic risk. They provide a non-invasive, non-antigenic, permeable, stable, soluble and receptor-specific way to transport drugs across the BBB and into the CNS.

  1. B. Oller-Salvia, M. Sánchez-Navarro, E. Giralt, M. Teixidó Chem. Soc. Rev. (2016), 45, 4690-4707.
  2. M. Sánchez-Navarro, E. Giralt, M. Teixidó Curr. Opin. Chem. Biol. (2017), 38, 134-140.
  3. M. Sánchez-Navarro, M. Teixidó, E. Giralt Acc. Chem. Res. (2017), 50, 1847-1854.
  4. R. Prades, B. Oller-Salvia, S. M. Schwarzmaier, J. Selva, M. Moros, M. Balbi, V. Grazú, J. M. de La Fuente, G. Egea, N. Plesnila, M. Teixidó, E. Giralt Angew. Chem. Int. Ed. (2015), 54: 3967-3972.
  5. B. Oller-Salvia, M. Sánchez-Navarro, S. Ciudad, M. Guiu, P. Arranz-Gibert, C. Garcia, R.R. Gomis, R. Cecchelli, J. García, E. Giralt, M. Teixidó Angew. Chem. Int. Ed. (2016), 55, 572-575.
  6. C. Dıaz-Perlas, M. Varese, S. Guardiola, J. García, M. Sánchez-Navarro, E. Giralt, M. Teixidó Chem. Commun. (2018), 54, 12738-1274.